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The present study with two Ayurvedic formulations reveals formulation-specific effects on several parameters of the fly's life, which seem to generally agree with their recommended human usages in Ayurvedic practices. Thus, Drosophila, with its very rich genetic tools and well-worked-out developmental pathways promises to be a very good model for examining the cellular and molecular bases of the effects of different Ayurvedic formulations.
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Iron deficiency anemia (IDA) is one of the most common nutritional deficiencies worldwide, which can be correlated to Pandu described in ayurvedic classics. Poor absorption of iron is one of the main reasons of IDA. Amalaki (Phyllanthus emblica L.) has Tridoshahara, especially Pittashamaka (pacifying Pitta) and Rasayana (rejuvenative) properties, thus nourishes the Dhatus and is also known to enhance the absorption of iron.
Caraka the renowned physician of Indian system of medicine recommended Cyavanaprasa for wide variety of ailments from paediatric to geriatric. So, the paper is focused on the result of the clinical study, that was conducted to evaluate the efficacy of Cyavanprasa in elderly volunteers. And the paper also highlights the step made through this clinical study to evaluate the weight of chief constituent i.e.500 number of fresh Amalaki (Emblica officinalis Gaertn) with proper ratio of sugar.
The results suggest that Triphala (300 mg/kg) has a considerable and reliable effect in reducing colitis in rats. This effect can be attributed to its antioxidant activity and well presence of flavonoids.
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A randomized controlled open clinical trial was conducted at Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar. Iron deficient anemic patients (n = 25) having Hb <12g% in females and 13g% in males and S.Iron <50mg/dl were selected and divided into two groups. Group A was given 2 g of Amalaki Rasayana thrice a day with unequal quantity of honey and ghee for 45 days, while Group B was given 150 mg ferrous fumarate + 1500 mcg folic acid (standard control) once a day with water for 45 days. Assessment was done on the basis of relief in cardinal symptoms of Pandu and hematological parameters.
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Both the samples are bitter and astringent with characteristic odor. RC is creamish brown in colour, while BRC is dark blackish brown. These Organoleptic characters were unchanged till the 6(th) month of study. On comparision, BRC is found to be more stable than RC.
Triphala, a herbal formula composed of the three fruits of Terminalia chebula Retz. (Haritaki, Family: Combretaceae), Terminalia bellirica Roxb. (Bibhitaki, Family: Combretaceae) and Phyllanthus emblica Linn. or Emblica officinalis Gaertn. (Amalaki or the Indian gooseberry, Family: Euphorbiaceae) is considered to be a universal panacea in the traditional Indian system of medicine the Ayurveda. It has been described in the Ayurveda text as a "Rasayana' and to rejuvenat the debilitated organs. Ayurvedic physicians use Triphala for many ailments but most importantly to treat various gastrointestinal disorders. Scientific studies carried out in the past two decades have validated many of the ethnomedicinal claims and researches have shown Triphala to possess free radical scavenging, antioxidant, antiinflammatory, antipyretic, analgesic, antibacterial, antimutagenic, wound healing, anticariogenic, antistress, adaptogenic, hypoglycaemic, anticancer, chemoprotective, radioprotective and chemopreventive effects. Clinical studies have also shown that Triphala was found to have good laxative property, to improve appetite and reduce gastric hyperacidity. Studies have also shown that Triphala was effective in preventing dental caries and that this effect was equal to that of chlorhexidine. The current review addresses the validated pharmacological properties of Triphala and also emphasizes on aspects that need further investigation for its future clinic application.
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Significant improvement was observed in clinical signs and symptoms along with plasma glucose and glycosylated hemoglobin (HbA1c) in Madhumeha patients after these interventions (P < 0.001).
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Test drugs were prepared by following classical guidelines. Wistar strain albino rats of either sex were used in the study.
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Intake of Amalaki rasayana by aged individuals showed stable maintenance of DNA strand break repair without toxic effects. However, there was no change in nucleotide and base excision repair activities. Results warrant further studies on the effects of Amalaki rasayana on DSBR activities.
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Over 90% of the sites for floressence and amalaki had at least one red flag. In these searches, sites with no red flags provided some scientifically accurate information, while sites with red flags provided a large amount of vague and inaccurate information. Less than one-quarter of sites for selenium had at least one red flag, and sites in this search generally provided scientifically accurate information, regardless of the number of red flags.
Decoction and alcoholic extract of Amalakyadi Gana has moderate antipyretic activity in rats, which may be due to inhibition of the synthesis and/or release of local PGE2. Further, Amalakyadi Gana has mild analgesic effect through central and peripheral mechanism. The result of the present study provide further scope for development of new palatable dosage form and tested clinically for better efficacy.
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The authors tested a strategy for screening Internet sites to identify those that provide scientifically accurate information regarding complementary/alternative medicine treatments commonly used by cancer patients.
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Chewable tablets were prepared by wet granulation method. Here, Āmalaki powder was prepared initially and it was mixed with additives and preservatives. Granules were prepared from this mixture by adding binding agent, finally compressed in to tablets.
There is a staggering amount of medical misinformation on the Internet. For cancer treatments that have not been rigorously studied, the red flag criteria offer a rapid way of screening Internet sites for likely scientific accuracy. It may be advisable for patients to avoid sites with one or more red flags.
Raw material was procured from The Pharmacy, Gujarat Ayurved University and authenticated at Pharmacognosy Laboratory. Individual drugs were powdered and blended in specified ratio to obtain Rasayana Churna (RC). RC was levigated with decoction of Amalaki, Guduchi and Gokshura to prepare Bhavita Rasayana Churna (BRC). Both the samples were subjected to accelerated stability studies by following standard guidelines.
The research team evaluated daily energy intake, fasting plasma glucose, serum lipid profile, and liver cytology. The team measured food and energy intake daily for 10 weeks and measured the body weight of each mouse every third day during the course of the experiment. The team drew blood samples at 2, 4, 8, and 10 weeks posttreatment and determined fasting plasma-glucose concentrations and fasting plasma concentrations of cholesterol, triglycerides (TG), LDL, HDL, and plasma alanine transaminase (ALT) using commercial kits. At the completion of the study, a pathologist examined the livers and diagnosed a fatty liver based on the presence of macrovesicular or microvesicular fat in the hepatocytes.
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Herbal products from Ayurveda were always in the forefront in providing leads to new drug discovery. Triphala, an ancient Ayurvedic herbal formulation comprises of equal portions of Amalaki, Bibhitaki and Haritaki and is used extensively for constipation, as an anti-inflammatory, analgesic, anti-arthritic, hypoglycemic and an anti-aging agent.
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Ayurveda represents the traditional medicine system of India. Since mechanistic details of therapy in terms of current biology are not available in Ayurvedic literature, modern scientific studies are necessary to understand its major concepts and procedures. It is necessary to examine effects of the whole Ayurvedic formulations rather than their "active" components as is done in most current studies.
The present study deals with antimicrobial activity of ayurvedic drugs containing single herb (Amalaki Choorna and Yastimadhu Choorna) and combination of herbs (DN-90 and Asanadi Kwatha Choorna). Disc diffusion method was used to assess antibacterial activity and antifungal activity was tested using Poison food technique. Absence of bacterial growth around the discs impregnated with the aqueous extracts of drugs and reduction of fungal growth in poisoned plates indicated antimicrobial activity. Further, the results of antibacterial activity of Amalaki choorna were comparable with standard drug Streptomycin. Asanadi Kwatha Choorna inhibited bacteria to more extent than Yastimadhu choorna and DN-90. Among fungi tested, more antifungal activity was observed against Mucor sp. The antimicrobial activity of drugs tested could be due to active principles present in them.
Separate Internet searches were conducted for three complementary/alternative medicine treatments: floressence, amalaki, and selenium. Sites (N=194) were assessed according to four criteria: availability of online purchasing, inclusion of patient testimonials, description of the treatment as a "cancer cure," and description of the treatment as "having no side effects." The presence of any of these criteria was considered a "red flag" denoting questionable scientific accuracy of the site. Sites were categorized based on the number of red flags. MEDLINE searches were performed and peer-reviewed literature used to determine the scientific accuracy of sites.
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In yeast-induced pyrexia model, both dosage forms of test drug produced marked decrease in rectal temperature after 3 h, 6 h, and 9 h among which extract produced statistically significant decrease after 6 h compared to control group. In the tail flick method, both forms of test drug showed insignificant increase in tail flick response after 180 and 240 min compared to control group and in formalin induced paw liking model decoction form of test drug significantly increased the latency of onset of paw licking and decreased the paw licking in early phase while alcoholic extract produced insignificant effect compared to control group.
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Concept of Saviryta Avadhi (shelf-life) of Ayurvedic dosage forms is well-defined in classics of Ayurveda. Information on this is scattered in initial classics of Ayurveda like Charaka Samhita, but focused well after 13(th) Century AD in texts such as Vangasena Samhita, Sharangadhara Samhita and Yogaratnakara. Though the concepts have a strong background; considering the pharmaceutical development, a need is felt to re-evaluate the age old concepts by following current norms.
Dhatryarishta has been described for the first time in Charaka Samhita, in the context of Panduroga. The same reference is available in Chakradatta, Bhaishajya Ratnavali, and Sahastrayogam too. Generally Dhatri Swarasa [Amalaki (Emblica officinalis Gaertn.)] is used in the preparation of Dhatryarishta as per classical reference, but fresh Amalaki is not available in every season, so in the present study, Amalaki Kwatha (decoction) is used instead of Swarasa. A total of 13 batches of Dhatryarishta were prepared, out of which nine batches were prepared with Dhatri Swarasa and four batches with Dhatri Kwatha. For Dhatryarishta prepared by using Dhatri Swarasa, three methods were applied and in Dhatryarishta prepared by using Dhatri Kwatha two methods were applied. The study revealed that Dhatryarishta could only be prepared by using Amalaki Swarasa as quoted in the classics and not by using Amalaki Kwatha.